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Combination of black walnut and natural plant ingredients that relieve digestive upsets äó˘ Traditionally used in Herbal Medicine as a digestive tonic to aid digestion and help relieve dyspepsia äó˘ Quassia, black walnut, and pumpkin seeds are traditionally used in Herbal Medicine as a vermifuge äó˘ Provides 400 mg of black walnut hull, quassia bark, and yarrow flower per daily dose äó˘ Includes 200 mg each of gentian root and pumpkin seed extract, 300 mg of sweet wormwood herb and 100 mg of clove bud per daily dose Black Walnut Capsules is a blend of herbs that are traditionally used in Herbal Medicine to help alleviate digestive disturbances. Black walnut, quassia, wormwood and gentian root all contain extremely bitter compounds, including tannins, quassin, absinthin, and amarogentin.1-4ŚćThese bitters cause nerves on the taste buds to increase the release of saliva and gastric juices that aid in digestion.4ŚćBitters can also bind receptors on endocrine cells of the gastrointestinal tract and pancreas, which results in the secretion of the peptide hormone cholecystokinin.5ŚćIn turn, this releases bile salts and pancreatic digestive enzymes, increasing gastric motility.5ŚćGentian root and quassia may help relieve dyspepsia by increasing prostaglandin-mediated cytoprotection in the gastric membrane; prostaglandins stimulate the release of mucous and sodium bicarbonate in the stomach.2,6,7ŚćQuassia, black walnut and pumpkin seeds are also traditionally used in Herbal Medicine as a vermifuge (helps in the expulsion of parasitic worms). REFERENCES 1. Milind, P, Deepa, K. International Research Journal of Pharmacy. 2011; 2(5): 8-17. 2. Ocampo, R, Mora, G. (2011). In M. Rai, D. Acharya, JL. Rios (Eds.), Ethnomedicinal Plants Revitalization of Traditional Knowledge of Herbs (pp. 301-332). Boca Raton, FL: Taylor & Francis Group, LLC. 3. Levit, A, Nowak, S, Meyerhof, W, Behrens, M, Peters, M, Niv, MY. FASEB Journal. 2014; 28(3): 1181-1197. 4. Godstime, O, Felix, E, Augustina, J, Christopher, E. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014; 2(2):77-85. 5. Valussi, M. International Journal of Food Sciences and Nutrition. 2012; 63(S1): 82_89. 6. Niiho, Y, Yamazaki, T, Nakajima, Y, Yamamoto, T, Ando, H, Hirai, Y, Toriizuka, K, Ida, Y. J Nat Med. 2006; 60: 82_88. 7. Wallace, JL. Physiol Rev. 2008; 88: 1547_1565.